Skip to content →

research publications

Peer-Reviewed Publications (* indicates undergraduate authors)   [view non-graphical list]

  1. “Determining sequential micellization steps of bile salts with multi-CMC modeling,” Rovnyak, D.; He, J.*; Kong, S.*; Eckenroad, K. W.*; Manley, G. A.*; Geffert, R. M.*; Krout, M. R.; Strein, T. G. J. Colloid Interface Sci. 2023, 644, 496-508; DOI: 10.1016/j.jcis.2023.03.146. [supplemental information]

  2. “Human gut bacteria produce ΤΗ17-modulating bile acid metabolites,” Paik, D.; Yao, L.; Zhang, Y.; Bae, S.; D’Agostino, G. D.; Zhang, M.; Kim, E.; Franzosa, E. A.; Avila-Pacheco, J.; Bisanz, J. E.; Rakowski, C. R.*; Vlamakis, H.; Xavier, R. J.; Turnbaugh, P. J.; Longman, R. S.; Krout, M. R.; Clish, C. B.; Rastinejad, F.; Huttenhower, C.; Huh, J. R.; Devlin, A. S. Nature 2022, 603, 907–912; DOI: 10.1038/s41586-022-04480-z. [supporting information]

    Preprint uploaded to Biorxiv on January 9, 2021.
  3. “Bile acid metabolites control Th17 and Treg cell differentiation,” Hang, S.; Paik, D.; Yao, L.; Kim, E.; Jamma, T.; Lu, J.; Ha, S.; Nelson, B. N.; Kelly, S. P.*; Wu, L.; Zheng, Y.; Longman, R. S.; Rastinejad, F.; Devlin, A. S.; Krout, M. R.; Fischbach, M. A.; Littman, D. R.; Huh, J. R. Nature 2019, 575, 143-148; DOI: 10.1038/s41586-019-1785-z. [supporting information]

    Preprint uploaded to Biorxiv on November 8, 2018.
  4. “Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides,” Fulton, T. J.*; Townsend, K. M.*; Krout, M. R. J. Visualized Exp. 2019, 147, e59775; DOI: 10.3791/59775.
  5. “Access to Functionalized Quaternary Stereocenters via the Copper-Catalyzed Conjugate Addition of Monoorganozinc Bromide Reagents Enabled by N,N-Dimethylacetamide,” Fulton, T. J.*; Alley, P. L.*; Rensch, H. R.; Ackerman, A. M.*; Berlin, C. B.*; Krout, M. R. J. Org. Chem. 2018, 83, 14723–14732; DOI: 10.1021/acs.joc.8b02201. [supporting information]
  6. “Wolff/Cope Approach to the AB Ring of the Sesterterpenoid Variecolin,” Krout, M. R.; Henry, C. E.; Jensen, T.; Wu, K.-L.; Virgil, S. R.; Stoltz, B. M. J. Org. Chem. 2018, 83, 6995–7009; DOI: 10.1021/acs.joc.7b02972. [supporting information]
  7. “Resolved P-Metalated Nucleoside Phosphoramidites,” Miller, E. J.*; Garcia, K. J.*; Holahan, E. C.*; Ciccarelli, R. M.*; Bergin, R. A.*; Casino, S. L.*; Bogaczyk, T. L.*; Krout, M. R.; Findeis, P. M.; Stockland, Jr., R. A. Inorg. Chem. 2014, 53, 12680–12682; DOI: 10.1021/ic5024357. [supporting information]
  8. “Palladium-Catalyzed Asymmetric Alkylation in the Synthesis of Cyclopentanoid and Cycloheptanoid Core Structures Bearing All-Carbon Quaternary Stereocenters,” Hong, A. Y.; Bennett, N. B.; Krout, M. R.; Jensen, T.; Harned, A. M.; Stoltz, B. M. Tetrahedron 2011, 67, 10234–10248; DOI: 10.1016/j.tet.2011.10.031. [supporting information]
  9. “Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies,” Behenna, D. C.; Mohr, J. T.; Sherden, N. H.; Marinescu, S. C.; Harned, A. M.; Tani, K.; Seto, M.; Ma, S.; Novák, Z; Krout, M. R.; McFadden, R. M.; Roizen, J. L., Enquist, Jr., J. A.; White, D. E.; Levine, S. R.*; Petrova, K. V.*; Iwashita, A.; Virgil, S. C.; Stoltz, B. M. Chem.—Eur. J. 2011, 17, 14199–14223; DOI: 10.1002/chem.201003383. [supporting information]
  10. “Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity,” Huh, J. R.; Leung, M. W. L.; Huang, P.; Ryan, D. A.; Krout, M. R.; Malapaka, R. R. V.; Chow, J.; Manel, N.; Ciofani, M.; Kim, S. V.; Cuesta, A.; Santori, F. R.; Lafaille, J. J.; Xu, H. E.; Gin, D. Y.; Rastinejad, F.; Littman, D. R. Nature 2011, 472, 486–490; DOI: 10.1038/nature09978. [supporting information]
  11. “Ring-Contraction Strategy for the Practical, Scalable, Catalytic Asymmetric Synthesis of Versatile γ-Quaternary Acylcyclopentenes,” Hong, A. Y.; Krout, M. R.; Jensen, T.; Bennett, N. B.; Harned, A. M.; Stoltz, B. M. Angew. Chem., Int. Ed. 2011, 50, 2756–2760; DOI: 10.1002/anie.201007814. [supporting information]
  12. “Preparation of (S)-2-allyl-2-methylcyclohexanone (Cyclohexanone, 2-methyl-2-(2-propen-1-yl)-, (2S)-),” Mohr, J. T.; Krout, M. R.; Stoltz, B. M. Org. Synth. 2009, 86, 194–211; DOI: 10.15227/orgsyn.086.0194.
  13. “Preparation of (S)–tert-ButylPHOX (Oxazole, 4-(1,1-dimethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro- (4S)-),” Krout, M. R.; Mohr, J. T.; Stoltz, B. M. Org. Synth. 2009, 86, 181–193; DOI: 10.15227/orgsyn.086.0181.
  14. “Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone,” Levine, S. R.*; Krout, M. R.; Stoltz, B. M. Org. Lett. 2009, 11, 289–292; DOI: 10.1021/ol802409h. [supporting information]
  15. “Natural products as inspiration for the development of asymmetric catalysis,” Mohr, J. T.; Krout, M. R.; Stoltz, B. M. Nature 2008, 455, 323–332; DOI: 10.1038/nature07370.
  16. “Synthesis of 2-Quinuclidonium by Eliminating Water: Experimental Quantification of the High Basicity of Extremely Twisted Amides,” Ly, T.; Krout, M.; Pham, D. K.; Tani, K.; Stoltz, B. M.; Julian, R. M. J. Am. Chem. Soc. 2007, 129, 1864–1865; DOI: 10.1021/ja067703m. [supporting information]

Patents

  1. Littman, D. R; Huh, J. R.; Manel, N. G. A.; Gin, D. Y.; Krout, M. R.; Ryan, D. A. “Steroid Compounds as RORγt Modulators and Uses Thereof,” U.S. Patent 20140066391 A1, March 6, 2014.
  2. Hanney, B.; Kim, Y.; Krout, M. R.; Meissner, R. S.; Mitchell, H. J.; Musselman, J.; Perkins, J. J.; Wang, J. “N-Benzyl-2-phenylbutanamides as tissue-selective androgen modulators, their preparation, pharmaceutical compositions, and use in therapy,” U.S. Patent 20050277681 A1, December 15, 2005.

Comments are closed.